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UFC 322 is set to feature a high-stakes welterweight championship clash between newly crowned champion Jack Della Maddalena and the formidable Islam Makhachev, with expert predictions from SportsLine’s Daniel Vithlani guiding bettors through the extensive fight card. The highly anticipated event will take place on Saturday, November 15, 2025, at the iconic Madison Square Garden in New York City. The main card is scheduled to commence at 10 p.m. ET, following the early preliminaries at 6 p.m. ET and the preliminary card at 8 p.m. ET.
The main event pits Australia’s Jack Della Maddalena against Russia’s Islam Makhachev in a contest with significant implications for both fighters and their respective divisions. Della Maddalena, who recently claimed the welterweight championship by defeating Belal Muhammad at UFC 315 in May, faces a challenging first title defense. His opponent, Islam Makhachev, is making a highly anticipated move up in weight class, bringing with him an impressive 15-bout winning streak that has established him as one of the sport’s most dominant figures.
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In the latest UFC 322 odds provided by DraftKings Sportsbook, Islam Makhachev enters the main event as the favorite at -298 (requiring a $298 wager to win $100). Jack Della Maddalena, the reigning champion, is positioned as the underdog at +240. The co-main event features another championship bout, with Valentina Shevchenko (-148) defending her women’s flyweight title against challenger Zhang Weili (+124).
For those seeking informed betting strategies, SportsLine expert Daniel Vithlani has released his comprehensive MMA predictions and betting advice for UFC 322. Vithlani has distinguished himself as a highly analytical UFC bettor, maintaining a consistent winning record for SportsLine members since his debut in January 2023. His inaugural appearance at UFC 283 saw him achieve a perfect 5-0 record, and he has since accumulated over $1,500 in profits from his UFC main-card picks.
Vithlani’s track record includes several notable upset calls, demonstrating his ability to identify value in the market. At UFC 292, he successfully predicted Sean O’Malley (+210) to defeat the heavily favored Aljamain Sterling (-250) as part of a 4-1 main card performance. Furthermore, his picks for UFC 299 included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). His consistent success across various events has positioned him as a trusted voice for sports betting enthusiasts utilizing various platforms and betting apps.
New users engaging with DraftKings can leverage a promotional offer providing $300 in bonus bets upon a winning wager, alongside three months of NBA League Pass. Similarly, the Underdog promo code "CBSSPORTS2" offers $100 in site credits when a user plays $5 in select states.
Della Maddalena vs. Makhachev: A Deep Dive into the Championship Main Event
Jack Della Maddalena, at 29 years old, has embarked on a remarkable professional journey since his debut in March 2016. Despite losing his initial two professional fights, he has remained undefeated since, demonstrating significant growth and resilience. His path to the UFC included a unanimous decision victory over Ange Loosa in Dana White’s Contender Series 39 in September 2021, securing his place in the premier mixed martial arts organization. His UFC debut at UFC 270 in January 2022 saw him defeat Pete Rodriguez by TKO, signaling his arrival in the welterweight division. With a professional record of 18-2, Della Maddalena’s striking prowess is evident with 12 victories coming by knockout, complemented by two submissions and four decisions.
Della Maddalena’s burgeoning career has been recognized with numerous accolades, including ESPN’s 2022 UFC Men’s Rookie of the Year and Cageside Press’s 2022 Co-Newcomer of the Year alongside Jailton Almeida. UFC.com also named him their 2022 Newcomer of the Year. He has earned four Performance of the Night bonuses and two Fight of the Night honors, underscoring his exciting fighting style and ability to deliver memorable performances. Currently ranked No. 8 in the UFC men’s pound-for-pound rankings, Della Maddalena’s ascent to the welterweight throne has been rapid and impressive, setting the stage for a challenging first defense against a grappling phenom.
Opposing him is the 34-year-old Islam Makhachev, whose professional career began in August 2010. Makhachev commenced his career with an impressive 12-bout winning streak, which included his UFC debut in May 2015, where he secured a submission victory over Leo Kuntz at UFC 187. Following his sole professional loss to Adriano Martins later that year, Makhachev has embarked on a dominant run, compiling a 15-bout winning streak that has established him as one of the most formidable fighters across all weight classes. His professional record stands at 27-1, with five victories by knockout, 13 by submission, and nine by decision, highlighting his well-rounded, yet grappling-heavy, approach.
Makhachev’s legacy is firmly cemented in the lightweight division, where he was a former UFC lightweight champion. He successfully defended his title an unprecedented four times before making the strategic decision to move up to the welterweight division. His performances have also garnered recognition, earning him three Fight of the Night and three Performance of the Night awards. He holds the record for most UFC lightweight title wins with five and is tied for the most consecutive UFC title defenses at four. Furthermore, his 15-fight winning streak places him alongside Kamaru Usman for the second-longest win streak in UFC history, underscoring the monumental challenge Della Maddalena faces. This move to welterweight represents Makhachev’s ambition to become a two-division champion, a feat that would further elevate his standing in the sport. The stylistic clash between Della Maddalena’s sharp striking and Makhachev’s elite grappling and wrestling will be a central narrative of this championship encounter.
Co-Main Event: Shevchenko vs. Weili for Women’s Flyweight Gold
The co-main event promises another thrilling championship contest as Valentina Shevchenko defends her women’s flyweight title against the formidable Zhang Weili. Shevchenko, known for her exceptional technical prowess, striking accuracy, and defensive grappling, has been a dominant force in the division. Her reign has been characterized by consistent performances against top contenders, solidifying her status as one of the pound-for-pound best female fighters. She enters the bout as the -148 favorite, reflecting her established dominance.
Challenging her is Zhang Weili, a former strawweight champion known for her explosive power, aggressive striking, and relentless pace. Weili’s transition to the flyweight division for this title shot adds another layer of intrigue, as she brings her high-pressure style to a new weight class. As the +124 underdog, Weili aims to dethrone one of the sport’s most decorated champions and secure a second UFC title in a different division. The clash of Shevchenko’s precision and technique against Weili’s raw power and aggression is anticipated to be a captivating encounter.
Expert Insights and Preliminary Card Highlights
Daniel Vithlani’s UFC 322 predictions extend beyond the main events. One of his highlighted picks involves backing Chepe Mariscal (-102) to secure a small upset victory against Pat Sabatini (-118) in a featherweight matchup on the early preliminary card.
Vithlani provided detailed rationale for this selection, stating, "Mariscal is now 5-0 in the UFC and hasn’t lost a fight since 2020. He is a scrappy fighter who welcomes a nasty affair. Mariscal uses his pace, pressure and grittiness to intimidate his opponents and wear on them. His volume-striking attack makes him dangerous, but it’s his ability to grapple and scramble that give him the edge in this matchup. Sabatini is a Ju-Jitsu ace, with 13 of his 19 pro wins coming by submission. He is a savvy grappler who can keep his opponents pinned to the mat. However, I have a hard time seeing him do that to Mariscal, who has never been submitted in his 18-6 pro career. Mariscal has a 73% takedown defense rate and has shown the ability to get up when taken down. If this fight plays out on the feet, Mariscal’s relentlessness will overwhelm Sabatini." This analysis underscores Vithlani’s emphasis on stylistic matchups and fighter resilience.
Full UFC 322 Main Fight Card and Odds:
The UFC 322 main card features several other compelling matchups, with odds subject to change:
- Jack Della Maddalena (+240) vs. Islam Makhachev (-298) – Welterweight Championship
- Valentina Shevchenko (-148) vs. Zhang Weili (+124) – Women’s Flyweight Championship
- Sean Brady (-142) vs. Michael Morales (+120) – Welterweight Bout
- Leon Edwards (+140) vs. Carlos Prates (-166) – Lightweight Bout
- Beniel Dariush (+160) vs. Benoit Saint-Denis (-192) – Lightweight Bout
Further analysis and complete betting cards from Daniel Vithlani are available on SportsLine, including a specific prediction for a fighter whose "constant barrage of strikes and takedowns" is projected to secure a significant victory. SportsLine offers comprehensive insights into all bouts on the UFC 322: Della Maddalena vs. Makhachev card, detailing how each fight is expected to unfold. Those interested in detailed picks and analysis from the expert who is up over $1,500 on his UFC main-card picks can visit SportsLine for his complete breakdown and predictions.
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