Anshari TaslimThe penultimate weekend of the 2025 college football regular season, Week 13, presents a critical juncture for numerous programs vying for a spot in the College Football Playoff (CFP). While the anticipation for "Rivalry Week" and the season’s final full slate looms, Saturday, November 22, 2025, features pivotal matchups that carry significant weight for national championship aspirations, alongside a robust schedule of professional basketball and hockey. Two all-ranked college football contests headline the day, with the most prominent being a high-stakes encounter between No. 15 USC and No. 7 Oregon, now both members of the Big Ten Conference.
The highly anticipated clash between USC and Oregon, set for 3:30 p.m. ET in Eugene, Oregon, marks a significant moment for the newly aligned Big Ten. The Ducks, currently holding a 9-1 record, enter the contest with a clear path to the CFP: a home victory against the Trojans would elevate them to 10-1, positioning them favorably for a playoff berth with potentially two or fewer regular-season losses. Head Coach Dan Lanning’s squad is aiming for its second consecutive CFP appearance, seeking to avenge a "humiliating Rose Bowl defeat to Ohio State" following a 13-0 regular season in the previous year’s playoff. Their sole loss this season came at home to No. 2 Indiana, a result that underscores the competitiveness within the new conference landscape. Oregon’s potent offense and aggressive coaching philosophy under Lanning have been central to their success, contributing to high-scoring affairs throughout the season. Following this pivotal matchup, Oregon is slated for a rivalry clash against Washington, another key Big Ten fixture.
Conversely, No. 15 USC, with an 8-2 record, faces a make-or-break situation. A third loss would "very likely eliminate USC from the CFP race," ending their aspirations for what would be the school’s "first CFP appearance in school history." The Trojans secured a crucial victory last week against Iowa, demonstrating their capacity to compete within the Big Ten. However, their road performance this season, standing at 2-2, indicates potential vulnerabilities away from home environments. USC’s offense, known for its high-powered attack under Head Coach Lincoln Riley, will need to be at its most efficient to overcome Oregon’s defensive challenges. The team’s schedule after this contest includes a game against a "lowly UCLA team," but the immediate focus remains on securing a signature win in Eugene. SportsLine’s projection model favors a high-scoring affair, pegging the Over on a total of 59.5 points, one of the highest totals on the Week 13 slate. SportsLine expert Thomas Casale specifically targets "Oregon’s team total Over 34.5," citing "USC’s run defense as a disadvantage" in the matchup, suggesting that the Ducks’ ground game could exploit Trojan weaknesses. The aggressive offensive strategies employed by both coaching staffs are expected to contribute to a contest rich in scoring opportunities.
Earlier in the day, at 12 p.m. ET, No. 22 Missouri travels to Norman, Oklahoma, to face No. 8 Oklahoma in another critical SEC matchup for the 2025 season. The Sooners, boasting an 8-2 record, are riding a wave of confidence after securing a significant "win of the week in Week 12" by "going to Tuscaloosa and handing Alabama its second loss of the year." This victory has bolstered Oklahoma’s "inside track to the playoff," with the team aiming to win its final two games to solidify its position. The Sooners are favored at home against a Missouri squad that, despite being ranked, is considered "shorthanded." Missouri’s 8-3 record, with losses to Alabama, Vanderbilt, and Texas A&M, has effectively "eliminated [them] from the CFP race." The Tigers’ offensive strategy has shifted to a "run-heavy offense" led by freshman quarterback "Matt Zollers," following an injury to starter "Beau Pribula," who remains questionable for the game. Missouri’s objective now centers on concluding its season on a positive note despite the playoff setback. The SportsLine Projection Model indicates confidence in the Sooners, not only predicting them to win outright but also covering the -6.5 spread in approximately half of its 10,000 simulations.
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Beyond the collegiate gridiron, Saturday’s sports schedule encompasses a wide array of events. College basketball features numerous matchups across the country, while professional sports offer seven NBA games and twelve NHL contests.
The NBA slate includes a compelling matchup at 8 p.m. ET between the Detroit Pistons and the Milwaukee Bucks in Milwaukee. The Detroit Pistons, under Head Coach J.B. Bickerstaff, have undergone a significant transformation, now holding a 13-2 record and the "second-most wins in the NBA." Their impressive "11-game win streak" underscores a remarkable ascent from winning just 14 games two seasons prior, to a 44-38 record and a playoff appearance last year. This rapid improvement positions them as a formidable force in the Eastern Conference. In contrast, the Milwaukee Bucks are experiencing a downturn, with an 8-8 record and having "dropped three in a row and six of their last 10" games. Despite their current struggles, the Bucks historically held the upper hand against their division rival, sweeping the season series 4-0 last year. This game marks the first meeting between the two teams this season. The SportsLine model identifies value in backing the underdog Bucks, not only on the money line but also predicting them to cover the +8.5 spread in "60% of simulations," suggesting potential for a bounce-back performance at home.
Looking ahead to Sunday, November 23, the NFL schedule presents an intriguing AFC matchup as the Indianapolis Colts visit the Kansas City Chiefs at 1 p.m. ET. The records for this game defy preseason expectations, with the "upstart Colts team" holding an impressive 8-2 record, positioning them as a "legit contender for the No. 1 seed in the conference." Indianapolis has seen a "rejuvenated Daniel Jones" at quarterback, complemented by an "elite rushing attack with Jonathan Taylor." The Colts have secured "notable wins" against teams like the Broncos and Chargers but have struggled in "big tests" against the Rams and Steelers. For Head Coach Shane Steichen’s squad, a road victory at Arrowhead Stadium would represent a "signature win." The Kansas City Chiefs, meanwhile, find themselves in an uncharacteristic position with a 5-5 record. A recent loss to Denver has "likely end[ed] the franchise’s streak of nine consecutive AFC West titles," placing pressure on them to "get back on track just to make the postseason." The SportsLine model favors the Chiefs to win outright and cover the -3.5 spread. However, SportsLine expert R.J. White offers a contrarian view, endorsing "Indianapolis +3.5." White’s analysis points to "Indy [having] the league’s top offense and a better defense statistically than the Chiefs." He further notes that "turnovers have been the only thing to trip up the Indy offense, yet the Chiefs defense managed no turnovers against five of the six top teams its faced, losing four of those games," concluding that the spread "should close no higher than 3 everywhere and I would probably take Indy at that number as well."
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