Ali Akbar Rosady
The Ultimate Fighting Championship (UFC) is set to host a pivotal heavyweight title clash on Saturday, October 25, 2025, as reigning champion Tom Aspinall defends his undisputed crown against the formidable No. 1 contender Ciryl Gane. The highly anticipated main event, headlining UFC 321: Aspinall vs. Gane, will unfold at the Etihad Arena on Yas Island in Abu Dhabi, United Arab Emirates, with the main card commencing at 2 p.m. ET following preliminary bouts that begin at 10 a.m. ET.
Tom Aspinall’s ascent to the pinnacle of the heavyweight division has been marked by explosive performances and a rapid trajectory. The 32-year-old British fighter was officially promoted to undisputed champion on June 21, 2025, solidifying his status after an impressive run. His journey to the undisputed title began in November 2023 at UFC 295, where he claimed the interim UFC heavyweight championship with a decisive knockout victory over Sergei Pavlovich. Aspinall then successfully defended his interim title in July 2024 at UFC 304, delivering another spectacular knockout against Curtis Blaydes. This victory over Blaydes was particularly significant, marking a redemption for Aspinall, who had previously suffered a TKO loss to Blaydes in July 2022 due due to a knee injury just 15 seconds into their bout. The comeback against Blaydes underscored Aspinall’s resilience and determination.
Hailing from Manchester, England, Aspinall made his professional debut in December 2014 and transitioned to the UFC in July 2020. His career record stands at an impressive 15-3, with 12 victories coming by way of knockout and three by submission, showcasing his diverse finishing capabilities. Aspinall’s fighting style is characterized by remarkable speed and agility for a heavyweight, combined with potent striking and a surprisingly dangerous ground game. His aggressive approach has earned him seven Performance of the Night bonuses, tying him for the fourth-most in UFC history. Furthermore, Aspinall holds the record for the shortest average fight time in UFC history at just 2 minutes and 2 seconds, a testament to his propensity for quick finishes. He also ranks second in knockdowns per 15 minutes, averaging 4.09. His exceptional performances have not gone unnoticed, earning him ninth place for UFC Newcomer of the Year in 2020, third for UFC Submission of the Year in 2022, and two prestigious MMA awards in 2024: Breakthrough Fighter of the Year and Comeback of the Year. For UFC 321, Aspinall enters the Octagon as the favorite, currently listed at -345 odds (requiring a $345 wager to win $100) at DraftKings Sportsbook.
Challenging Aspinall for the heavyweight gold is Ciryl Gane, the 35-year-old French standout known as "Bon Gamin." Gane, fighting out of Paris, France, boasts a professional record of 13-2. His path to this title shot saw him secure a split decision victory over Alexander Volkov at UFC 310 last December, a crucial win that re-established his position at the top of the heavyweight rankings. Gane began his professional fighting career in August 2018, quickly making a name for himself with three consecutive knockout wins, which caught the attention of the UFC. He made his promotional debut in August 2019, securing a submission win over Raphael Pessoa at UFC Fight Night: Shevchenko vs. Carmouche 2. Gane’s initial UFC run was spectacular, as he remained undefeated through his first 10 professional bouts, culminating in a third-round knockout of Derrick Lewis in August 2021, which earned him the interim UFC heavyweight championship and a Performance of the Night bonus.
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Gane’s fighting style is distinctive for a heavyweight, blending fluid movement, technical kickboxing, and powerful strikes. His record includes six wins by knockout, three by submission, and four by decision, demonstrating his versatility. He was recognized as the UFC’s second-ranked Newcomer of the Year in 2019 and the No. 3 Fighter of the Year in 2021. In 2022, his third-round knockout of Tai Tuivasa at UFC Fight Night: Gane vs. Tuivasa was ranked as the seventh-best Fight of the Year. Gane, having previously competed for the undisputed title against Francis Ngannou, brings invaluable championship experience to this bout. He stands as the underdog in this championship encounter, with current odds at +275, meaning a $100 bet on Gane would yield a $275 profit if he upsets the champion.
The co-main event features a women’s strawweight championship bout between Mackenzie Dern and Virna Jandiroba. Dern is currently favored at -148, while Jandiroba is listed at +124. Dern is renowned for her elite Brazilian Jiu-Jitsu prowess, holding numerous world championships in grappling before transitioning to MMA. Jandiroba, a former Invicta FC Strawweight Champion, is a well-rounded fighter with strong grappling and improving striking.
For bettors looking to make informed decisions on UFC 321, SportsLine expert Daniel Vithlani has released his comprehensive MMA predictions and betting advice. Vithlani, a highly analytical UFC bettor, has established a consistent winning record for SportsLine members since his debut in January 2023, notably starting with a perfect 5-0 record for UFC 283. His main-card sports betting picks have generated over $1,500 in profit for followers. Among his notable calls are predicting the upset victory of Sean O’Malley (+210) against Aljamain Sterling (-250) at UFC 292, contributing to a 4-1 main card performance. Vithlani’s successful picks at UFC 299 included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130).
Vithlani has thoroughly analyzed the Tom Aspinall vs. Ciryl Gane matchup from multiple angles, alongside other bouts on the UFC 321 card. One of his revealed preliminary card selections backs Jose Delgado (-155) to defeat Nathaniel Wood (+130) in a featherweight matchup scheduled for approximately 11:45 a.m. ET.
Regarding this pick, Vithlani stated, "Delgado is a rising featherweight prospect who looks to be legitimate. Training out of the MMA Lab gym, Delgado is a rangy and explosive striker who throws nasty knees and elbows. In his last fight, Delgado knocked out a fighter with great durability in under 30 seconds. Standing 5-foot-11 with a 73-inch reach, Delgado is big for the weight class and will have a considerable size advantage. Wood is a tactical kickboxer with strong UFC experience, and he will provide a step-up in competition for Delgado. However, I don’t think he’ll be able to outpoint Delgado for three rounds. Delgado is the more dangerous and aggressive fighter, and he’s never been finished in his young 10-1 pro career. I think Delgado’s size and pressure will win him this fight."
For those interested in betting opportunities, new users can leverage the DraftKings promo code, which offers $300 in bonus bets if their initial wager wins, plus three months of NBA League Pass. Additionally, new users can target the Underdog promo code, providing $100 in site credits when playing $5 with the promo code CBSSPORTS2 in select states. The FanDuel promo code also offers new users $300 in bonus bets instantly if their initial $5 bet wins.
Vithlani’s complete set of picks for UFC 321, including his detailed analysis for the Aspinall vs. Gane main event and other significant bouts, are available exclusively at SportsLine. He is also reportedly backing a fighter on the card who "will use a physicality and wrestling edge" to secure a crucial victory.
The full main fight card for UFC 321, with current odds (subject to change), is as follows:
- Tom Aspinall (-345) vs. Ciryl Gane (+275) – UFC Heavyweight Championship
- Virna Jandiroba (+124) vs. Mackenzie Dern (-148) – Women’s Strawweight Championship
- Umar Nurmagomedov (-625) vs. Mario Bautista (+455) – Bantamweight Bout
- Alexander Volkov (+164) vs. Jailton Almeida (-198) – Heavyweight Bout
- Aleksandar Rakic (-118) vs. Azamat Murzakanov (-102) – Light Heavyweight Bout
Fans and bettors alike can visit SportsLine for in-depth picks and analysis from the expert who has consistently delivered profitable outcomes on UFC main-card selections.
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