The Ultimate Fighting Championship (UFC) heavyweight title will be on the line this Saturday, October 25, 2025, as reigning champion Tom Aspinall prepares to face the formidable No. 1 contender Ciryl Gane in the main event of UFC 321. The highly anticipated card, dubbed "Aspinall vs. Gane," is set to unfold at the Etihad Arena on Yas Island/Yas West, United Arab Emirates, with the main card commencing at 2 p.m. ET and the preliminary bouts kicking off at 10 a.m. ET.
Tom Aspinall, a dynamic force in the heavyweight division, enters the octagon as the undisputed champion, a status he achieved on June 21, 2025. His path to the undisputed crown began with a decisive knockout victory over Sergei Pavlovich at UFC 295 in November 2023, securing the interim UFC heavyweight championship. He successfully defended this interim title against Curtis Blaydes at UFC 304 in July 2024, avenging a previous loss from July 2022. Aspinall’s meteoric rise since his professional debut in December 2014 in Manchester, England, and subsequent UFC debut in July 2020, has been marked by a staggering finishing rate and rapid victories. His professional record stands at 15-3, boasting 12 wins by knockout and three by submission, underscoring his versatile and aggressive fighting style.
Aspinall’s career has been punctuated by numerous accolades, including an impressive seven "Performance of the Night" bonuses, tying him for the fourth-most in UFC history. His fights are notoriously short, holding the record for the shortest average fight time in UFC history at just 2 minutes and 2 seconds, a testament to his explosive power and clinical finishing ability. Furthermore, he ranks second in UFC history for knockdowns per 15 minutes, averaging 4.09. His talent was recognized early, earning him a ninth-place ranking for "UFC Newcomer of the Year" in 2020 and the third spot for "UFC Submission of the Year" in 2022. More recently, 2024 saw him capture two significant MMA awards: "Breakthrough Fighter of the Year" and "Comeback of the Year," solidifying his status as a dominant and resilient competitor.
Across the octagon, Ciryl Gane, known as "Bon Gamin," poses a significant threat. Hailing from Paris, France, Gane, 35, is a former interim UFC heavyweight champion himself and is celebrated for his unique, fluid striking style and exceptional athleticism for a fighter of his size. Gane’s professional journey began in August 2018, quickly garnering attention with knockout wins in his first three bouts. He made his UFC debut in August 2019, securing a submission victory over Raphael Pessoa at UFC Fight Night: Shevchenko vs. Carmouche 2. His initial run saw him undefeated through his first 10 professional fights, a streak that included a third-round knockout of Derrick Lewis in August 2021, which earned him the interim UFC heavyweight championship and a "Performance of the Night" bonus. Gane’s overall professional record is an impressive 13-2, with six wins by knockout, three by submission, and four by decision, demonstrating his well-rounded skill set. His most recent outing was a split decision victory over Alexander Volkov at UFC 310 in December of the previous year (2024), a testament to his ability to adapt and secure wins even in closely contested matchups. Gane’s impact on the sport has been acknowledged with a second-place ranking for "UFC Newcomer of the Year" in 2019 and a third-place ranking for "Fighter of the Year" in 2021. In 2022, his thrilling third-round knockout of Tai Tuivasa at UFC Fight Night: Gane vs. Tuivasa was recognized as the seventh-ranked "Fight of the Year."
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Betting Outlook and Expert Analysis
The latest odds from DraftKings Sportsbook position Tom Aspinall as the clear favorite at -345 (requiring a $345 risk to win $100), reflecting his recent dominance and comprehensive skill set. Ciryl Gane enters as the underdog at +275, a value proposition for bettors who believe in his technical prowess and ability to upset the champion.
In the co-main event, the women’s strawweight championship will see Mackenzie Dern (-148) favored against Virna Jandiroba (+124) in what is expected to be a grappling-heavy contest.
For those looking to place informed wagers, SportsLine expert Daniel Vithlani has provided comprehensive MMA predictions and betting advice for UFC 321. Vithlani has established himself as a highly analytical and consistent winner for SportsLine members since his debut in January 2023, where he posted a perfect 5-0 record for UFC 283. His insights have led to over $1,500 in profit on his UFC main-card sports betting picks. Notably, Vithlani correctly predicted Sean O’Malley’s upset victory (+210) over Aljamain Sterling (-250) at UFC 292, part of a successful 4-1 main card. His expertise continued at UFC 299, where he picked underdog selections Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130), further demonstrating his keen eye for value and upset potential.
Vithlani’s detailed analysis extends to every bout on the UFC 321 card. One of his disclosed selections for the preliminary card is Jose Delgado (-155) to defeat Nathaniel Wood (+130) in a featherweight matchup, scheduled for approximately 11:45 a.m. ET.
Regarding this pick, Vithlani stated, "Delgado is a rising featherweight prospect who looks to be legit. Training out of MMA Lab gym, Delgado is a rangy and explosive striker who throws nasty knees and elbows. In his last fight, Delgado knocked out a fighter with great durability in under 30 seconds. Standing 5-foot-11 with a 73-inch reach, Delgado is big for the weight class and will have a considerable size advantage. Wood is a tactical kickboxer with strong UFC experience, and he will provide a step-up in competition for Delgado. However, I don’t think he’ll be able to outpoint Delgado for three rounds. Delgado is the more dangerous and aggressive fighter, and he’s never been finished in his young 10-1 pro career. I think Delgado’s size and pressure will win him this fight."
Promotional Offers for New Bettors
New users interested in sports betting for UFC 321 can take advantage of several promotional offers. The DraftKings promo code offers $300 in bonus bets if your initial bet wins, alongside three months of NBA League Pass. For those exploring daily fantasy sports, the Underdog promo code "CBSSPORTS2" provides $100 in site credits when you play $5 in select states. Additionally, new users at FanDuel can utilize the latest FanDuel promo code to receive $300 in bonus bets instantly if their qualifying $5 bet wins.
UFC 321 Main Fight Card and Odds
Beyond the headline attractions, UFC 321 features a compelling lineup of bouts across various weight classes, with significant implications for their respective divisions.
- Heavyweight Championship: Tom Aspinall (-345) vs. Ciryl Gane (+275)
- Women’s Strawweight Championship: Virna Jandiroba (+124) vs. Mackenzie Dern (-148)
- Bantamweight: Umar Nurmagomedov (-625) vs. Mario Bautista (+455)
- Heavyweight: Alexander Volkov (+164) vs. Jailton Almeida (-198)
- Light Heavyweight: Aleksandar Rakic (-118) vs. Azamat Murzakanov (-102)
The light heavyweight clash between Aleksandar Rakic and Azamat Murzakanov is particularly intriguing, with both fighters closely matched in the odds and looking to climb the ranks in a competitive division. Similarly, the heavyweight bout featuring Alexander Volkov and Jailton Almeida pits two contrasting styles against each other, with the winner potentially positioning themselves for future title contention. In the bantamweight division, the undefeated Umar Nurmagomedov faces Mario Bautista, a fight that could further cement Nurmagomedov’s status as a top contender.
Expert predictions for all these matchups, including a detailed breakdown of how the Aspinall-Gane main event might conclude and a fighter Vithlani believes "will use a physicality and wrestling edge" to secure a major victory, are available through SportsLine.
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