Ali Akbar Rosady
The Ultimate Fighting Championship (UFC) heavyweight division is poised for a monumental clash as reigning champion Tom Aspinall prepares to defend his undisputed title against the formidable No. 1 contender Ciryl Gane at UFC 321. The highly anticipated event is scheduled for Saturday, October 25, 2025, emanating from the Etihad Arena on Yas Island in Abu Dhabi, United Arab Emirates, with the main card commencing at 2 p.m. ET following the preliminary bouts which begin at 10 a.m. ET. This championship encounter pits two of the division’s most dynamic athletes against each other in a contest that promises significant implications for the heavyweight landscape.
Tom Aspinall’s ascent to the pinnacle of the heavyweight division has been marked by a series of dominant performances and rapid finishes. The 32-year-old Briton initially claimed the interim UFC heavyweight championship in November 2023 with a spectacular knockout victory over Sergei Pavlovich at UFC 295, a fight that underscored his explosive power and precision. He further solidified his claim by successfully defending the interim title against Curtis Blaydes in July 2024 at UFC 304, another impressive knockout win that also served as a redemption for his prior loss to Blaydes in July 2022 due to injury. Aspinall’s consistent excellence and proven ability to finish opponents led to his promotion to undisputed champion on June 21, 2025. With a professional record of 15-3, Aspinall boasts an impressive finishing rate, securing 12 victories by knockout and three by submission. Since making his professional debut in December 2014 out of Manchester, England, and subsequently his UFC debut in July 2020, Aspinall has compiled 11 wins in his last 12 outings. His statistical prowess within the UFC is notable; he holds the record for the shortest average fight time in UFC history at just 2 minutes and 2 seconds, reflecting his propensity for quick and decisive finishes. Furthermore, he ranks second in knockdowns per 15 minutes at 4.09, highlighting his striking efficacy. Aspinall’s performances have garnered widespread acclaim, earning him Performance of the Night honors seven times, a distinction tied for the fourth-most in UFC history. His contributions to the sport have also been recognized through various accolades, including being ranked ninth for UFC Newcomer of the Year in 2020, third for UFC Submission of the Year in 2022, and receiving two MMA awards in 2024 for Breakthrough Fighter of the Year and Comeback of the Year.
Challenging Aspinall for the heavyweight strap is Ciryl Gane, a fighter renowned for his exceptional movement and technical striking, atypical for a fighter of his stature. The 35-year-old "Bon Gamin," fighting out of Paris, France, entered the professional mixed martial arts scene in August 2018, swiftly making an impact with three consecutive knockout victories that caught the attention of the UFC. He made his promotional debut in August 2019, securing a submission win over Raphael Pessoa at UFC Fight Night: Shevchenko vs. Carmouche 2. Gane’s initial run in the UFC was flawless, as he went on to win his first 10 professional bouts. This streak included a third-round knockout of Derrick Lewis in August 2021, which earned him the interim UFC heavyweight championship and a Performance of the Night bonus. Gane’s overall professional record stands at 13-2, with six wins by knockout, three by submission, and four by decision, showcasing his versatility. He has consistently been recognized for his contributions to the sport, ranking as the second-best UFC Newcomer of the Year in 2019 and the third-best Fighter of the Year in 2021. In 2022, his third-round knockout victory over Tai Tuivasa at UFC Fight Night: Gane vs. Tuivasa was ranked as the seventh-best Fight of the Year. Gane’s most recent outing saw him secure a split decision victory over Alexander Volkov at UFC 310 last December, reinforcing his position as the top contender.
The stylistic matchup between Aspinall and Gane presents a fascinating dynamic. Aspinall’s aggressive, high-pressure style, characterized by explosive power and a well-rounded skill set that includes proficient grappling, will be tested against Gane’s fluid movement, tactical striking, and impressive defensive capabilities. Gane’s ability to maintain distance and pick apart opponents with precise jabs and kicks could pose a challenge to Aspinall’s charge. Conversely, Aspinall’s speed and ability to close the distance quickly, combined with his formidable ground game, could disrupt Gane’s rhythm and force him into uncomfortable positions. Both fighters possess the knockout power to end the fight at any moment, making this heavyweight title fight a highly anticipated spectacle.
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According to the latest UFC 321 odds from DraftKings Sportsbook, Tom Aspinall enters the contest as the favorite at -345, requiring a wager of $345 to yield a $100 profit. Ciryl Gane is listed as the underdog at +275, meaning a $100 bet would return $275 if he emerges victorious.
Beyond the main event, UFC 321 features a compelling co-main event and a stacked fight card with significant matchups across various divisions. In the women’s strawweight championship bout, Mackenzie Dern is the -148 favorite against Virna Jandiroba, who is listed at +124. Dern, a world-class Brazilian Jiu-Jitsu practitioner, will look to leverage her grappling advantage against Jandiroba, another highly skilled grappler with improving striking. The card also includes an intriguing bantamweight clash between the undefeated Umar Nurmagomedov (-625), a fighter with an impressive grappling pedigree from the renowned Nurmagomedov lineage, and Mario Bautista (+455). A heavyweight showdown between Alexander Volkov (+164) and Jailton Almeida (-198) is also on tap, promising another potential finish. In the light heavyweight division, Aleksandar Rakic (-118) faces Azamat Murzakanov (-102) in a tightly contested bout that could have title implications.
For those seeking expert insight into the UFC 321 card, SportsLine MMA analyst Daniel Vithlani has provided his predictions and betting advice. Vithlani has established a strong track record since his debut in January 2023, where he achieved a 5-0 record for UFC 283. He has consistently delivered winning picks for SportsLine members, accumulating over $1,500 in profits on his UFC main-card selections. His notable successes include correctly predicting Sean O’Malley’s upset victory (+210) over Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card. At UFC 299, Vithlani identified underdog winners in Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130).
Vithlani has meticulously analyzed the entire UFC 321 card, including the Aspinall vs. Gane main event, and has released his top betting picks. One specific preliminary card selection revealed by Vithlani is Jose Delgado (-155) to defeat Nathaniel Wood (+130) in a featherweight matchup, estimated to begin around 11:45 a.m. ET. Providing his rationale, Vithlani stated, "Delgado is a rising featherweight prospect who looks to be legit. Training out of MMA Lab gym, Delgado is a rangy and explosive striker who throws nasty knees and elbows. In his last fight, Delgado knocked out a fighter with great durability in under 30 seconds. Standing 5-foot-11 with a 73-inch reach, Delgado is big for the weight class and will have a considerable size advantage. Wood is a tactical kickboxer with strong UFC experience, and he will provide a step-up in competition for Delgado. However, I don’t think he’ll be able to outpoint Delgado for three rounds. Delgado is the more dangerous and aggressive fighter, and he’s never been finished in his young 10-1 pro career. I think Delgado’s size and pressure will win him this fight." Vithlani’s complete set of picks, including his prediction for the main event and another fighter he believes "will use a physicality and wrestling edge" to secure a significant victory, are available exclusively through SportsLine.
For those interested in betting on UFC 321, various promotional offers are available for new users. DraftKings Sportsbook is offering $300 in bonus bets if a user’s initial bet wins, alongside three months of NBA League Pass. Underdog Fantasy provides $100 in site credits when playing $5 with the promo code CBSSPORTS2 in select states. Additionally, FanDuel Sportsbook allows new users to receive $300 in bonus bets instantly if their initial $5 wager is successful. These promotions offer opportunities for new bettors to engage with the event.
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